Travel by bus

Many times with these discussions you often read about people traveling by car, plane, or boat. It's not often that the subject of long distance bus travel is brought up. Preparation is key for these trips. Most bus services require 48 hours notice for those that need medical assistance or have issues. Plus, the bus drivers and personnel will need to be notified at stops if you have special needs. Have you ever gone on a long distance bus trip? What was your experience like?